Document Details
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Document Type |
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Article In Journal |
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Document Title |
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Biochemical bone turnover markers (BTMs) provide important information on the diagnosis, therapy and monitoring of metabolic bone diseases including osteoporosis. القياسات المرجعية للواسمات الكيموحيوية للواسمات العظمية الهدم بنائية في النساء السعوديات: دراسة متعددة الجوانب |
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Subject |
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الغدد الصماء – هشاشة العظام |
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Document Language |
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English |
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Abstract |
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Biochemical bone turnover markers (BTMs) provide important information on the diagnosis, therapy and monitoring of metabolic bone diseases including osteoporosis. One goal of anti-resorptive therapy in women is to decrease biochemical BTMs to the lower half of reference intervals for healthy premenopausal counterparts, using newly developed automated assays of such markers. The main objectives of the present study were to: (1) establish reference interval values for the following biochemical BTMs: serum osteocalcine (s-OC), bone alkaline phosphatase (s-bone ALP), procollagen type 1 N-terminal propeptide (s-PINP), crosslinked C-terminal telopeptide of Type 1 collagen (s-CTX), tartarate-resistant acid phosphatase isoform 5b (s-TRACP-5b) and urinary: CTX (u-CTX), N-telopeptides of type 1 collagen (u-NTX), pyridinoline (u-PYD) and deoxypyridinoline (u-DPD) in randomly selected Saudi healthy premenopausal women; (2) study the changes in biochemical BTMs in relation to age in pre- and postmenopausal women and the factors reported to influence bone turnover and (3) determine the effect of menopausal status on BTMs. A total of 2125 women were studied [including (n=1557) pre-, and (n=568) postmenopausal women, respectively, aged 20-79 years]. A total of 765 healthy premenopausal women (aged 35-45 years) were used to establish reference intervals for biochemical BTMs. All women studied were medically examined and had their bone mineral density (BMD) values obtained for the lumber spine (L1-L4) and femoral neck according to a detailed inclusion criteria. In all women, values of biochemical BTMs, decreased with increasing age up to the age of 45 years, increased steeply among women in their 50s and remained increased in postmenopausal women. Significant increases were evident in all biochemical BTMs in postmenopausal women with >5 years since menopause with the exception of s-OC, u-DPD, and u-PYD. Using stepwise multiple linear regression analysis, several variables were identified (depending on the BTM) as determinants of BTMs including age, BMI, parity, FSH, LH, PTH, s-Ca, s-Mg, s-PO4 and 25(OH)D. In the reference intervals group, no significant correlations between any of the biochemical BTMs and age of menarche, day of menstrual cycle, physical activity, total daily dietary calcium and caffeine intakes and parity. It is recommended that the age range 35-45 years should be used when establishing biochemical BTMs reference intervals in Saudi Arabian premenopausal women. |
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ISSN |
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8756-3282 |
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Journal Name |
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Bone |
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Volume |
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1 |
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Issue Number |
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7 |
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Publishing Year |
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1431 AH
2010 AD |
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Article Type |
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Article |
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Added Date |
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Sunday, August 1, 2010 |
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Researchers
| محمد صالح العرضاوي | Ardawi, Mohammed s | Investigator | | ardawims@yahoo.com |
| عبد الرؤوف ميمني | Maimani, Abdulraoof | Researcher | Doctorate | |
| طلال محمد بخش | Bahksh, Talal Mohammed | Researcher | Doctorate | |
| عبد الرحيم علي روزي | Rozi, Abdulrahem Ali | Researcher | Doctorate | |
| محمد حسن قاري | Qari, Mohammed Hassan | Researcher | Doctorate | |
| رجاء محمد الردادي | Al Radadi, Rajaa Mohammed | Researcher | Doctorate | |
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